United produced a valiant comeback to register a draw with Southampton at the weekend, but Jose Mourinho's side head into this fixture without a win in three games in the top flight.
Arsenal - on the other hand - are unbeaten in their last 12 matches in the Premier League, and have not suffered defeat in any competition since the second weekend of the season.
The Gunners hold an eight-point advantage over United ahead of Wednesday's showdown at Old Trafford.
MANCHESTER UNITED: De Gea; Bailly, Smalling, Marcos Rojo, Dalot, Herrera, Matic, Darmian; Lingard, Rashford, Martial
MANCHESTER UNITED SUBSTITUTES: Romero, Valencia, Fellaini, Mata, McTominay, Pogba, Lukaku
ARSENAL: Leno; Sokratis, Mustafi, Holding; Bellerin, Torreira, Guendouzi, Kolasinac; Ramsey, Iwobi, Aubameyang
ARSENAL SUBSTITUTES: Cech, Lichtsteiner, Maitland-Niles, Elneny, Mkhitaryan, Nketiah, Lacazette
The full-time whistle goes at Old Trafford and the two teams have played out a 2-2 draw. Arsenal will be disappointed having twice led and created the better opportunities, but United were probably deserving of a point. Thanks for joining our live coverage of the match!
90+6 min Manchester United 2-2 Arsenal
90+3 min Bailly is down with cramp. It's not really a surprise given his lack of appearances.
90+1 min There will be four minutes of added-on time.
90 min Arsenal put together a fine move down the right with Mkhitaryan deceiving two players before crossing for Torreira, who sees a first-time effort well saved by De Gea. Mkhitaryan produces the most brilliant of finishes from the rebound but he is a yard offside.
89 min This game is petering out a little now. I think both teams will be content with a point, if that is how it stays.
87 min Fellaini has just pulled the hair of Guendouzi. There is clearly some jealousy there. Nothing comes from the resulting set piece.
86 min Rashford takes it upon himself to get a shot away from 30 yards out, but the strike is straight at Leno.
84 min The chances have dried up since I mentioned that there will surely be another goal. I will keep my mouth shut. United are in possession now, but in their own half.
82 min Arsenal are winning the midfield battle at this stage, and it's probably why United are taking the direct approach. Eight to go. Still no more chances.
80 min As I say that, United start to launch the ball into the penalty area in the hope of getting Lukaku into the action. The Belgian has not really been involved since his introduction.
78 min Arsenal are showing the greater intent to win this match but it is giving United more space at the back. I really cannot see this remaining 2-2.
76 min SUBSTITUTION! United make a third change and Pogba is on for Lingard.
75 min There surely has to be another goal in this game. Aubameyang attempts to find the far corner with a long-range curler, but De Gea gets across to parry the ball away.
74 min SUBSTITUTION! A second alteration from United sees Fellaini come on for Rojo.
72 min Arsenal squander two chances to go back in front! Aubameyang should convert from six yards after meeting Kolasinac's cross, only for De Gea to stick out a leg, and then Mkhitaryan somehow fires over from three yards out!
69 min Some of the defending in this game has been appalling and it's no different here. Straight from the kickoff, the ball is sent forward and after Kolasinac diverts the ball back towards his own goal, Lingard reacts fastest to poke a shot past Leno!
69 min Manchester United 2-2 Arsenal (Jesse Lingard)
68 min The visitors retake the lead and again, it's a weird one. Lacazette plays a one-two with Mkhitaryan and although Rojo gets across to prevent the shot, he can only kick the ball against the Frenchman and the ball finds the bottom corner!
68 min Manchester United 1-2 Arsenal (Alexandre Lacazette)
66 min The action has slowed down a touch now, which is most definitely to Arsenal's liking. They need a period to regroup and to find the right balance. Mkhitaryan and Aubameyang will not do the same defensive work as Ramsey and Iwobi.
64 min SUBSTITUTION! Emery is not hanging around. Lacazette is introduced into the action and Iwobi makes way.
63 min SUBSTITUTION! United have an injury concern now and it sees Lukaku replace Martial.
61 min Better from Arsenal who again target the left flank to get forward. Nothing comes from it, but it at least makes United think for a few seconds. That hadn't been the case for about 10 minutes.
59 min Rojo is given the chance to get a shot away from distance and the Argentine sees an effort tipped over the bar by Leno. The ball was heading over, but the goalkeeper helped it on its way.
58 min Emery has just one alteration up his sleeve. If he had more, you would think that he would tinker with his team because they are simply second best now. Mourinho has plenty of options in reserve too.
56 min It's all United now. Dalot is released down the right flank and he has plenty of time to pick out a teammate. The wing-back probably has too much because he can only find the first man.
54 minYet another injury for Arsenal, this time for Torreira. This would be disastrous. However, the Uruguayan enforcer is back on his feet. Remember that Arsenal only have one more substitution.
52 min More of the same from both teams. It's taking a while for the two sides to get into their stride again. United are showing more ambition at this stage.
50 min Both teams are trying to create something going forward but the defences are on top at this stage. United are doing their best to step up, however. That wasn't the case during the second quarter of the first half.
48 min There's not a lot to report from the opening stages of the second half. Kolasinac thought that he should have won a corner having got into the penalty area, but the referee disagreed.
46 min United get us back underway.
45+3 min Manchester United 1-1 Arsenal
45+3 min Ramsey is really struggling with a knock picked up in a recent tackle. I think Emery will give it until the break to make a decision on the Wales international.
45+1 min There will be three minutes of added-on time.
44 min Just the minute to go until half time now. I think both teams will be happy to hear the whistle so that emotions can cool down.
42 min Anyone for another yellow card? Here you go. Matic tugs the shirt of Aubameyang to halt a counter-attack and it is a fifth yellow card in six minutes.
41 min This is unbelievable. Bellerin now enters the book for a foul on the right flank!
40 min Now Lingard is cautioned for a cynical trip on Torreira. Things are heating up!
38 min Rojo is also yellow carded for a late challenge on Guendouzi, who was trying to clear the ball from out of the penalty area.
37 min Mustafi goes into the book for a foul on Rashford as the England international attempted to cut inside on the byline. Easy decision for the referee.
36 min SUBSTITUTION! Lichtsteiner has been introduced for Holding and has taken his place on the right side of a back three.
36 min Arsenal win a corner on the right but it comes to nothing. The set piece had come from Ramsey having a shot deflected wide of the target.
34 min Play is back underway while Holding continues to receive treatment and it looks like Arsenal are going to have to make a change. That's a big blow for the visitors.
32 min We are going to have a break in play while Holding receives treatment on the sidelines. Both sets of players are probably pleased for the stoppage!
30 min There is your response. A free kick from Rojo is well saved by Leno but Herrera is able to get the ball back across goal for Martial to fire home from close range. Herrera was probably marginally offside, but the goal stands!
30 min Manchester United 1-1 Arsenal (Anthony Martial)
28 min United started this game on the front foot but within a quarter-of-an-hour, that had changed. Arsenal deserve their lead and it's now up to the home side to deliver a response.
26 min Arsenal take the lead and the defending and goalkeeping is abysmal. Mustafi mistimes a free header from a corner and it should be easy work for De Gea, However, the Spaniard fumbles the ball behind him and it goes just over the line, despite the best efforts of a defender.
26 min Manchester United 0-1 Arsenal (Shkodran Mustafi)
24 min It's been all Arsenal over the last five or six minutes. They are still to get a threatening shot away, but they are making all of the running.
22 min The visitors are fixating on trying to isolate Dalot and their tactics are working. The defender gets a good tackle in on this occasion but more often than not, it's two on one.
20 min Arsenal are getting closer and again, it's down the left. Kolasinac drills in a low cross and although Smalling can only half-clear the ball, Darmian is well positioned on the far side.
19 min That constant pressing from United has stopped now and Arsenal are now able to dictate play and put together moves from the back. They look settled while United are prepared to take a breather.
17 min Nothing came from the resulting corner, but it was at least a show of intent from Arsenal. The likes of Dalot and Darmian have been allowed to spend too much time in attacking areas.
15 min Better from the visitors who manage to get Iwobi down the left, but a defender comes across to divert his cross behind for a corner.
13 min The home side surge forward through Martial and the Frenchman has options either side. However, he instead tries a speculative effort from 25 yards which is easily claimed by Leno.
11 min United have been the better side during the early stages, but Arsenal are beginning to warm into this. No more shots to speak of, but it's been an entertaining opening.
9 min Martial wins a corner on the left and it's a chance for United's backline to get forward. However, the set piece is played short and eventually comes to nothing.
7 min Arsenal are finally starting to get their foot on the ball, but United are doing their best to close their opponents down and keep them in their own defensive third.
5 min Mourinho appears to have got his message across because his players are playing at a high pace. Rashford takes his chance to get a shot on goal from distance, but his well-struck effort from 25 yards is straight at Leno.
3 min It's been a quiet start from both sides, although United have had the one break forward with Rashford failing to pick out a teammate with a through-ball.
1 min Arsenal get us underway!
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