The system allows off-field referees to assist match officials regarding goals, penalty and straight red card decisions, and mistaken identity when awarding red and yellow cards.
VAR has been used once before in Africa, for the 2018 CAF Super Cup match between Wydad Casablanca of Morocco and TP Mazembe of the Democratic Republic of Congo.
While VAR has been both lauded and loathed by footballers and officials, its use at the World Cup in Russia this year was considered “largely successful” by FIFA.
“We used it for the Super Cup last February without any hitches and are delighted to go a step further,” CAF general secretary Amr Fahmy said.
“This is another historic moment for African football. CAF is determined to use the latest innovative technologies available.”
Record eight-time champions Ahly and twice trophy-holders Esperance have met 16 times at various stages of the Champions League, starting with two goalless 1990 qualifiers.
The most controversial refereeing decision came in a 2010 semi-final when Nigerian Michael Eneramo clearly handled when scoring the goal that won the tie for Esperance.
It was scant consolation to Ahly that the Ghanaian referee who allowed the goal to stand in Tunisia was banned.
Ahly and Esperance go into the two-leg title decider — the second leg is on November 9 in Tunisia — knowing a great deal about each other having also met in the group stage.
After a 0-0 draw in Egypt, Ahly won the return match 1-0 through a goal from Morocco-born Walid Azaro, one of six he netted in the Champions League this season.
Anice Badri of Esperance has scored one more with his seventh coming five minutes from time to secure overall victory in a dramatic semi-final against Primeiro Agosto of Angola.
Other potential match-winners in Alexandria and Rades include Haythem Jouini of Esperance, who has come off the bench to score vital goals.
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