The hosts only need a point tonight to secure their place in the last 16 of the competition with two games to spare, while victory would wrap up top spot in the group.
United, meanwhile, begin the day second in the group but are five points adrift of their opponents after being outclassed by them at Old Trafford a fortnight ago.
Make sure you don't miss a moment of the action courtesy of our minute-by-minute updates below.
JUVENTUS: Szczesny; De Sciglio, Chiellini, Bonucci, Alex Sandro; Khedira, Pjanic, Bentancur; Dybala, Cuadrado, Ronaldo
MANCHESTER UNITED: De Gea; Young, Smalling, Lindelof, Shaw; Herrera, Matic, Pogba; Lingard, Sanchez, Martial
Incredible. Who saw that coming?! Manchester United score twice in the final five minutes to produce an amazing comeback in Turin, beating Juventus 2-1 courtesy of goals from Juan Mata and a Leonardo Bonucci own goal - after Ronaldo had opened the scoring in such style.
It is a result every bit as impressive as their 3-2 win here in 1999 or their 3-0 triumph in 2003, and it is a much bigger shock than those two results as well! Thanks for joining our live coverage of the match!
90+6 min JUVENTUS 1-2 MANCHESTER UNITED
90+4 min Huge chance for United to seal the win as Martial drives forward before playing Rashford in, but Szczesny pulls off a really good save! Could that prove costly for United?
90+2 min JUVENTUS SUB: A third and final change for the hosts as Mario Mandzukic replaces Cuadrado.
90+1 min Bonucci tries to atone for that own goal with a long-range drive which flies a few yards wide.
90 min Oh my word, incredible scenes in Turin as United produce a stunning late turnaround to take the lead!
Young swings a deep free kick into the box which Fellaini just cannot reach, but which still causes problems. Players are racing in on top of Szczesny, who can only parry it out against Bonucci, who is helpless the ball bounces off him and over the line.
90 min JUVENTUS 1-2 MANCHESTER UNITED (LEONARDO BONUCCI, OWN GOAL)
88 min Cuadrado cuts inside before teeing up Dybala, but he tries to cut across it and gets it all wrong, firing his effort well wide.
88 min As things stand, that goal sends United back up to second in the group, above Valencia on goal difference. A big, big goal for the Red Devils!
86 min Brilliant from Mata! The Spaniard lines up the free kick and curls it over the wall and beyond Szczesny!
That is a huge goal for United, who are now just a few minutes away from a hugely impressive result in Turin
86 min JUVENTUS 1-1 MANCHESTER UNITED (JUAN MATA)
85 min...and now the visitors have a free kick in a very dangerous position after good work from Martial.
84 min United are not out of this one just yet! Martial gets down the left channel and puts the ball into the box which Szczesny palms out into the area and Chiellini then hacks away.
83 min JUVENTUS SUB: Another change from the hosts here as Andrea Barzagli replaces De Sciglio.
79 min United have an increasingly rare effort on goal as Rashford turns and then lets fly from range, but his low drive bounces wide of the target.
79 min MAN UTD SUBS: Double change for United here as Juan Mata and Marouane Fellaini replace Herrera and Sanchez.
77 min Juventus are peppering the United goal again now and De Gea is once again left as a mere spectator as he watches Pjanic's swerving drive fly just over the crossbar.
77 min Ronaldo lines the resulting free kick up from range, but his effort goes straight into the wall. Poor from the goalscorer.
75 min Strange one from the referee here as Dybala is hauled back by Herrera off the ball, only for both players to be shown a yellow card. Dybala didn't really do anything wrong there!
74 min Juventus should be out of sight by now! Another glorious chance goes begging as Cuadrado drives forward before giving the ball to Ronaldo, who cuts inside before giving it back. Cuadrado does not seem to be expecting the return pass, though, and spoons his finish over when he simply had to score.
73 min Another chance for Juventus to double their advantage as they pinch the ball off Pogba deep inside the Juventus half. The ball is teed up for Pjanic, but he gets his shot all wrong and puts it well wide when he would have at least expected to hit the target.
72 min UPDATE: Man City and Real Madrid cannot stop scoring tonight. Jesus has scored his second penalty of the night to make it 4-0 at the Etihad, while Toni Kroos has added a fifth for Real Madrid at Plzen. Meanwhile, 10-man Hoffenheim have pulled a goal back against Lyon and Bayern Munich have doubled their lead over AEK Athens.
70 min MAN UTD SUB: Change from the visitors here as Marcus Rashford replaces Jesse Lingard.
67 min Big chance for Juve to add a quickfire second as Ronaldo lays the ball into the path of Pjanic, whose first-time curling effort is parried away by De Gea before being hacked clear by Herrera.
65 min Oh my word! What a way to end your Champions League drought!
Ronaldo has just scored an absolute beauty to break the deadlock against his former club, lashing a stunning first-time volley past a helpless De Gea. Bonucci picked him out with a pass over the top, and Ronaldo watched it all the way over his shoulder before producing an unstoppable strike.
65 min JUVENTUS 1-0 MANCHESTER UNITED (CRISTIANO RONALDO)
64 min UPDATE: Ajax have levelled things up away to Benfica, but it is a long way back for Hoffenheim, who are now down to 10 men in addition to being two goals behind.
62 min Really good defending from Luke Shaw as he bravely gets a head to Ronaldo's dangerous cross from the left. Cuadrado was attacking it and Shaw got clattered for his troubles, but it was a vital piece of defending from the full-back.
61 min JUVENTUS SUB: Juve make their first change of the night as Blaise Matuidi replaces Khedira.
59 min United have battled very well in this game, but one player who is struggling to make an impact is Pogba. The game is passing the former Juve midfielder by tonight.
57 min De Sciglio goes bursting down the right flank, cruising past Pogba like he isn't there. However, the full-back's low cross is easily cut out.
55 min Sandro has picked up a yellow card for that challenge on Young, who is only now back to his feet.
52 min That is twice United have had to rely on the woodwork now - could it be their night? They still need to improve their attacking threat, although Martial's chance early in this second half was a positive start.
50 min Juventus are denied by the woodwork again! This time it is a brilliant effort from Dybala, who gets a potent mix of power, curl and dip on his effort from the edge of the box. De Gea doesn't even move before it flashes past him, but he turns around to see it crash off the crossbar!
49 min United create their best chance of the match so far as Martial dribbles inside before trying to curl an effort into the far corner which goes a couple of yards wide.
48 min UPDATE: Man City haven't taken long to get going in the second half - Raheem Sterling has made it 3-0 against Shakhtar.
46 min Juventus get us back underway for the second half at the Allianz Stadium!
We're still goalless at half time in Turin, then, and Manchester United will be pretty happy with how they have played in this match so far.
The possession and chances have fallen the way of Juventus, but United have by no means been overrun and are much more competitive in this game than they were at Old Trafford last month.
45+1 min JUVENTUS 0-0 MANCHESTER UNITED
45+1 min Ronaldo tries his luck late in the half from range and wins a corner out of it, with his strike taking a def lection and going a few yards wide.
45+1 min There will be a minimum of one minute added time at the end of this first half as Pogba curls a long-range effort towards goal which is gathered by Szczesny.
44 min UPDATE: Real Madrid are well and truly back to form now - they are four goals up before half time away to Plzen, with Bale joining the party.
43 min Dybala swings a free kick into a very dangerous area inside the box and it almost falls to Chiellini, but Herrera gets a crucial toe to it first.
41 min Better from United, but they are lacking a cutting edge in the final third at the moment. They have played with a lot more intensity tonight, but have not tested Szczesny in the Juve goal so far.
39 min United are hanging on a little bit towards the end of this first half. Juve are piling the pressure on right now and the visitors will just want to get to the interval without suffering any damage now.
37 min UPDATE: Real Madrid are now three goals to the good against Plzen through Benzema's second, while elsewhere Benfica and Bayern both lead against Lyon are two up against Hoffenheim.
35 min Juventus are inches away from taking the lead, but they really should be ahead! De Sciglio plays the ball down the right channel for Ronaldo, who in turn puts a low cross into the box. Khedira is unmarked, but he drags his effort against the foot of the post with De Gea beaten.
34 min Really smart stop from De Gea! Cuadrado drilled a low cross into the box from the right flank and it took a deflection off Matic on the way through, forcing De Gea to react quickly in order to keep it out.
33 min United fans may not be happy with the fact that Man City are already two goals to the good, and this is not likely to cheer them up. For the rest of us, though, it is laughable. This is how City were awarded the penalty which led to their second goal!
31 min United win a free kick in a really good position which Sanchez lines up, but his effort goes straight into the wall. Juve immediately break down the other end and Khedira powers a shot towards goal which De Gea needs to save.
29 min United have their brightest attacking moment of the match so far as Matic clips a pass over the defence towards Sanchez, who has timed his run into the box well but just cannot get on the end of the pass.
27 min United are proving a tough nut to crack tonight. Juventus are yet to fashion a really good chance and things are not proving as straightforward as many might have expected on the basis of the reverse fixture.
25 min UPDATE: Ominous signs for United ahead of the derby on Sunday as Man City are already 2-0 up against Shakhtar, with Gabriel Jesus doubling their lead from the spot. Madrid are also 2-0 up against Plzen now as Casemiro makes it a quickfire double for the defending champions.
23 min We're midway through the first half now and, while Juventus are on top right now, Mourinho will be much happier now than he was at the same stage of the reverse fixture. United are putting pressure on the ball and not letting Juventus have things all their own way, which simply wasn't the case at Old Trafford.
21 min UPDATE: A couple of other goals to update you on from elsewhere - Real Madrid lead against Plzen through Karim Benzema, while Nabil Fekir has broken the deadlock for Lyon against Hoffenheim.
19 min...but Pjanic's delivery is uncharacteristically poor and cleared by the first man.
18 min Juventus are slowly gaining a bigger element of control over this game, and they now have a free kick in a good crossing position...
16 min Ronaldo has his first shot of the night as he picks the ball up in space around 30 yards from goal and only ever has one thought in his mind. His shot is dipping, but flies wide with De Gea watching it all the way.
15 min UPDATE: The first goal of the 8pm kickoffs has gone to a Manchester team, but it is City who have taken the lead against Shakhtar through David Silva.
13 min United have started a lot better tonight than they did at Old Trafford, when they gave Juventus far too much room on the ball. However, Juve do look dangerous when they come forward and United will know that they cannot switch off for a second tonight.
12 min Matic picks up an early yellow card for a lunging scissor challenge on Dybala. No complaints there.
10 min Sandro drops the ball back to Bentancur on the edge of the area and the midfielder immediately looks to get a shot away, but his effort is deflected wide of the target.
9 min Pjanic clips a ball forward for Ronaldo, who kills it instantly inside the box but then cannot squeeze his shot past the defender.
8 min Dybala almost needed treatment before this game even began after Szczesny pelted a ball straight at his head!
6 min United have the chance to break after a poor Juventus corner, with Sanchez and Lingard leading the charge. The latter misplaces a simple pass, though, and a really good attacking platform goes begging.
5 min United have started this match brightly, looking to get on the front foot early on, but Juve have just had their first dangerous spell of possession and it took an important block from Lindelof to stop Ronaldo's volley from Dybala's effort.
3 min Poor from Szczesny as he boots the ball straight out of play with the first chance to have the ball at his feet. However, United waste the attacking platform with a foul throw.
1 min Here we go! Manchester United get us underway in Turin!
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