The hosts come into this match having won just one of their last six outings across all competitions, although they are unbeaten and yet to concede in the Champions League so far this season.
Juventus top Group H courtesy of two wins from two, though, and Massimiliano Allegri's side arrive at Old Trafford having won 10 and lost none of their opening 11 games of the campaign.
Make sure you don't miss a moment of the action courtesy of our minute-by-minute updates below.
MANCHESTER UNITED: De Gea; Young, Lindelof, Smalling,Shaw; Mata, Matic, Pogba; Rashford, Lukaku, Martial
JUVENTUS: Szczesny; Cancelo, Bonucci, Chiellini, Alex Sandro; Matuidi, Bentancur, Pjanic; Dybala, Cuadrado, Ronaldo
Juventus comfortably hold out for the victory at Old Trafford, with the hosts offering very little in response to Juve's dominance throughout the course of the 90 minutes.
Paulo Dybala scored the only goal of the game in the first half, but the 1-0 scoreline flatters United a little in truth, despite Pogba hitting the post with 15 minutes remaining. Thanks for joining our live coverage of the match!
90+3 min MANCHESTER UNITED 0-1 JUVENTUS
90+1 min There will be three minutes of added time at the end of this match.
90 min Good play from Martial as he spins away from his marker before driving towards goal and curling effort towards goal which is saved by the keeper.
89 min Shooting chance for Juve again as Bonucci finds himself as the furthest man forward, but he cannot keep his long-range drive down.
87 min JUVENTUS SUB: A third and final change for Juventus as Douglas Costa replaces Cancelo.
85 min A free kick is hoisted into the box and Matic climbs highest to meet it, but there is very little he can do with his header and Szczesny collects with ease.
84 min Almost a chance for United as Lukaku collects the ball inside the area and manages to carve out a half-shooting opportunity, but his effort takes a deflection on its way well off target.
83 min Chiellini picks up a yellow card for time-wasting.
82 min JUVENTUS SUB: Another change for the visitors sees Andrea Barzagli replace Cuadrado.
80 min There isn't too much Mourinho can do to influence this game now in all honesty. He has not got any real game-changers on his bench tonight and so may have to keep faith with the 11 on the field.
78 min JUVENTUS SUB: Juve make the first change of the night as Federico Bernardeschi replaces Dybala, who is not happy at being withdrawn.
77 min Ashley Young goes into the book for a cynical trip on Sandro.
77 min United are getting much more joy down the wings now, with the likes of Shaw and especially Young having a growing influence on the match. It looks like they may make a game of it after all!
75 min United finally threaten the Juventus goal as some lax play gifts possession to Pogba, who produces a good turn away from his man. The midfield then curls a low effort towards goal which hits the foot of the post before rebounding against Szczesny and wide of the post for a corner.
74 min Martial collects the ball inside the box and manages to get a cross away, but his low delivery is easy for the keeper to gather.
73 min Juve have been a class above tonight, all over the field. They have been so sturdy in defence and Bentancur and Pjanic in midfield have bossed this match.
71 min UPDATE: It is turning into quite the night for the blue half of Manchester - City have just made it 3-0 away to Shakhtar Donetsk through Bernardo Silva.
69 min Just over 20 minutes in this match and Juventus are still in control of this game. A 1-0 lead is never safe, but United have not shown many signs of getting an equaliser yet.
67 min UPDATE: It is turning into a thriller in Man City's group as Lyon - who led 1-0 but then trailed 2-1 - have swung the game back in their favour and now lead 3-2!
65 min The United fans are beginning to react to this improvement from their side as they finally begin to show a bit of urgency and attacking intent here. Still not much for Szczesny to do, but it has been better from the hosts in the last five minutes or so.
64 min This is better from United now! Smalling finds himself high up the field and he plays a low pass into the box which goes into a dangerous position, but Cancelo is the first to meet it and hack it clear.
63 min Here is that stunning save from De Gea to deny Ronaldo...
61 min Just under half an hour remaining in this match now and still United are yet to seriously test Szczesny. It has been far too easy for Juventus in this opening hour.
59 min Matuidi becomes the first name in the book this evening, and he can have no complaints after clattering in to Young.
58 min Matic swings it into the middle himself, but the offside flag is immediately raised against the United attackers.
57 min United are fortunate to get a free kick in a promising crossing position here after Mata seemed to throw himself to the ground. Can they make anything of this?
55 min UPDATE: Marcelo has been strongly linked with a move to Juventus, but he has just scored for Real Madrid to double their lead against Plzen.
53 min United pick up the ball in a good position once again, but they never really look set and Lukaku puts the ball behind Rashford which allows Juve to win it back.
52 min Brilliant stop from De Gea as he denies a thunderous strike from Ronaldo! It is a devastating team move from Juve which ends with Cuadrado teeing up Ronaldo on the edge of the box, and his powerful first-time effort is destined for the top corner before De Gea tips it over the top.
50 min Poor defending from United as Matuidi drives past Young and Pogba to get into the box far too easily, but his low pass into the middle is scuffed behind by Lindelof.
49 min UPDATE: More goals from elsewhere to tell you about, with Roma moving into a 3-0 lead against CSKA Moscow and Hoffenheim now leading Lyon 2-1 after coming from a goal down.
47 min Mata steals the ball off Pjanic inside the Juve half to launch an attack, but Martial sees one shot blocked before Pogba's volley hits Lukaku, who looks oblivious in the middle. Martial then feeds the ball back into the middle, but Chiellini does enough against Lukaku.
46 min Juventus get us back underway for the second half at Old Trafford!
The first half comes to an end at Old Trafford, and it is Juventus who have the lead against Manchester United at the halfway stage.
The Italian champions have dominated possession and controlled the vast majority of this game, and in truth could be further ahead having outclassed United so far.
45 min MANCHESTER UNITED 0-1 JUVENTUS
44 min Just a minute left plus stoppage time in this first half now and Juve have shown no signs of allowing their defence to be breached just yet. The hosts need to take more risks, with Pogba's header their only effort on target so far.
42 min Dybala threatens again here as he collects the ball just outside the area, works it onto his left foot and then curls his shot a few yards wide of the target.
41 min Bentancur picks up a loose ball in midfield after Shaw could only half-clear his lines, but the United defender makes up for it by blocking the subsequent effort.
40 min Just five minutes remaining in this first half now and United will know that they need to show more going forward if they are to get themselves back into the match. Szczesny has barely broken a sweat in the Juventus goal.
38 min Ronaldo lines up a free kick from range and stings the palms of De Gea with a powerful drive. The ball bounces back out to Matuidi, who fires his rebound into the ground and forces another stop from De Gea. Even then the danger is not over, though, and a cross arrives into the box which Matuidi nods off target.
35 min UPDATE: United may be struggling here, but Man City are having no such troubles and now lead Shakhtar Donetsk 2-0 in Ukraine through David Silva and Aymeric Laporte. Hoffenheim have also equalised against Lyon, while Roma lead CSKA Moscow.
33 min Juventus have the chance to break with Cuadrado leading the charge before sliding a pass through for Dybala. Lindelof defends well, though, and cuts out his pass back inside towards Ronaldo.
32 min Much better from United as they finally begin to put Juventus under some pressure. Chiellini is a tough man to beat, though, and he produces one really good tackle on Rashford before nodding a dangerous cross behind for a corner.
30 min Another big chance for Juventus as Bentancur meets a corner from the right flank, shrugging off his marker before nodding an effort over the crossbar when he probably should have done better.
29 min The frustration of the fans is growing now as Juve continue to dominate possession and control this game. United do not seem to be able to get close to their visitors at the moment.
28 min Juve again break into a dangerous position as Dybala is allowed to ghost into the area, where he is found unmarked by Pjanic. This time his subsequent low cross is cleared away, but United cannot allow them to break behind the defence so easily.
26 min UPDATE: There has been a goal elsewhere which will be of interest to Man City fans, with Lyon taking the lead against Hoffenheim in their group.
24 min Juventus are beginning to look very comfortable and dominant now. United are struggling to get into the game right now and it is the visitors who look far more likely to add to the scoring at the moment.
22 min Another opening for Juve as Cancelo plays a one-two with Ronaldo on his way into the box before drilling an effort across goal which De Gea needs to parry away.
21 min There may not be much between the sides in terms of goalmouth moments, but when it comes to possession it is all Juve at the moment. They have enjoyed 72% of the ball in this one so far.
19 min Once again United will be forced to come from behind if they are to get anything out of this game! There hasn't been much between these two sides, but the one telling moment has fallen the way of the visitors so far.
17 min Juventus break the deadlock at Old Trafford as Paulo Dybala opens the scoring!
Ronaldo is involved as he latches on to a pass down the right flank before firing a cross in towards the front post. Cuadrado makes the dart but is followed by Smalling, whose sliding interception only sees the ball pop up nicely for Dybala. The Argentine is free and unmaked, and left with a simple finish as he tucks it into the bottom corner past De Gea!
17 min MAN UTD 0-1 JUVENTUS (PAULO DYBALA)
16 min The first save of the night comes from Szczesny, but it is a simple one for the Juventus keeper. A free kick arrives a little bit behind Pogba, but he is still able to steer his header on target and Szczesny collects.
15 min UPDATE: The pressure on Julen Lopetegui could be easing a little tonight, with Real Madrid having taken the lead against Viktoria Plzen through Karim Benzema.
13 min Almost a chance for United as Dybala slides the ball out wide right for Cuadrado and continues his run into the box. The delivery finds him in space too, but it is just too high for him to steer a header towards goal.
11 min Ronaldo is brought down by Smalling inside the United half, and surprisingly doesn't appear to have any desire to hit it at goal. It is a long way out, though, and instead Pjanic floats a ball straight out of play.
9 min Poor from Shaw as his pass out of the defence was easily cut out by Pjanic, who immediately slid his pass in for Dybala. The Juve tries to cut inside onto his left foot, but he is dispossessed inside the area.
7 min Not much to shout about in the opening exchanges so far as both sides look to settle themselves into this game. Both appear to have done so nice and quickly too.
5 min The hosts then win another free kick in an almost identical position on the opposite flank, but Rashford's delivery is comfortably cleared.
4 min After a brief stoppage to play as a pitch intruder is dealt with, Mata's delivery is easily claimed by Szczesny.
3 min Rashford has his first chance to attack the defence down the right flank, and he wins a free kick by skipping away from Pjanic. United have a good crossing opportunity here...
1 min Here we go, then! Manchester United get us underway at Old Trafford!
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