The hosts come into this match unbeaten in their last 17 outings across all competitions, while they are yet to lose a single game at Anfield this season.
Man City have dropped just two Premier League points all term, though, and would move 18 points clear of second place with another victory this afternoon.
The reverse fixture saw City record a 5-0 win at the Etihad Stadium in September.
Make sure you don't miss a moment of the action courtesy of our minute-by-minute updates below.
LIVERPOOL: Karius; Gomez, Lovren, Matip, Robertson; Can, Wijnaldum, Oxlade-Chamberlain; Salah, Firmino, Mane
LIVERPOOL SUBS: Mignolet, Milner, Klavan, Lallana, Ings, Solanke, Alexander-Arnold
MANCHESTER CITY: Ederson; Walker, Stones, Otamendi, Delph; Fernandinho, De Bruyne, Gundogan; Sane, Sterling, Aguero
MANCHESTER CITY SUBS: Bravo, Zinchenko, Danilo, Mangala, D Silva, Bernardo, Diaz
What a game. An incredible contest at Anfield, which sees Liverpool hold out despite some heavy late pressure from Manchester City to end Pep Guardiola's side's dreams of an invincible season!
Three goals in the space of eight second-half minutes proved to be enough for Liverpool after Leroy Sane had earlier cancelled out Oxlade-Chamberlain's opener, although City certainly didn't go down with a whimper as late goals from Bernardo Silva and Gundogan gave them hope of a memorable comeback in the final 10 minutes. Thanks for joining our live coverage of the match!
90+5 min FULL TIME: Liverpool 4-3 Manchester City
90+4 min LIVERPOOL SUB: Liverpool make a change before the free kick is taken, with Ragnar Klavan replacing Mane.
90+4 min YELLOW CARD! Milner picks up a late yellow card as Man City win a free kick in a dangerous crossing position...
90+2 min Surely not?! Man City pull another goal back, and suddenly the comeback looks like it could well happen with two minutes of injury time still remaining!
Sane takes the ball inside before finding Aguero, who stands a cross up into the box. Gundogan somehow finds space in there to take the ball down on his chest and poke it past the keeper from close range!
90+2 min GOAL! Liverpool 4-3 Manchester City (Ilkay Gundogan)
90 min There will be four minutes of added time at the end of this match!
88 min LIVERPOOL SUB: Another change for the Reds here as Salah departs to be replaced by Adam Lallana.
86 min Liverpool have thrown away plenty of leads already this season, of course, so the fans may be biting their fingernails right now. City need to strike soon if they are to give themselves some real hope, though.
84 min A glimmer of hope for Man City, perhaps?
The visitors pull a goal back as Sane cuts inside from the left flank before seeing his shot well blocked. The ball only falls to the feet of Bernardo, though, and he tucks away his finish into the bottom corner. Nervy times ahead for Liverpool!
84 min GOAL! Liverpool 4-2 Man City (Bernardo Silva)
83 min SHOT! Liverpool break yet again and Firmino holds on to the ball before laying it off for Wijnaldum, who drills a low shot just wide of the target.
81 min Wijnaldum wins the ball just outside his own area and leads the charge for another counter-attack, but he is slow to get his head up and when he finally spots Mane's run the winger is offside.
79 min LIVERPOOL SUB: Change for the hosts here as James Milner replaces Can.
78 min CHANCE! Chance for City to pull one back and perhaps give themselves a glimmer as Otamendi sneaks in at the back post to get on the end of De Bruyne's cross, but he can't get anything on it to turn it back across the face of goal.
76 min Liverpool are hounding and chasing everything here, with Robertson ending up on the right wing due to his closing down. He wins the ball back alongside Firmino too, although the referee blows from a free kick to City inside their own box.
72 min YELLOW CARD! Fernandinho now joins his teammates in the book for a cynical challenge.
71 min MAN CITY SUB: Forget the goals, this may be the biggest cheer of the day as Sterling is withdrawn to be replaced by Bernardo Silva.
70 min YELLOW CARD! Sterling becomes the latest player in the book for a sliding challenge on Wijnaldum.
68 min Surely that is game over now! Liverpool extend their lead even further, and it is a poor mistake from Ederson of all people which gifts them it.
Salah plays a pass through which is easily mopped up by Ederson, but his clearance only sends it straight back to Salah. The Egyptian still has plenty to do, but he takes a touch before lofting it over the stranded keeper and into the empty net from all of 35 yards.
68 min GOAL! Liverpool 4-1 Manchester City (Mohamed Salah)
65 min YELLOW CARD! Otamendi picks up a yellow card for a cynical block on Salah down the right channel.
64 min Liverpool are absolutely flying now, and they believe that they can get more goals here. There is still time for Man City to get back into this game, but first they need to quell this Liverpool momentum.
62 min Incredible scenes at Anfield! Liverpool have two goals in as many minutes to send Man City well on course for their first league defeat of the season!
Mane, having missed a chance moments ago, picks up possession on the edge of the area before drilling a stunning strike right into the top corner, leaving Ederson so chance. Anfield is rocking!
62 min GOAL! Liverpool 3-1 Manchester City (Sadio Mane)
61 min OFF THE POST! Liverpool are inches away from a second in quick succession as Mane curls one from the edge of the box which clips the outside of the post on its way behind!
60 min Liverpool regain the lead with half an hour remaining, and it is a stunning finish from Roberto Firmino!
The Brazilian shrugs off Stones to get on the end of a pass forward, with the Man City defender beaten far too easily. From there, Firmino lifts an exquisite finish over Ederson and into the far corner. Brilliant finish.
60 min GOAL! Liverpool 2-1 Manchester City (Roberto Firmino)
58 min Almost an hour gone in this game now and this one could still go either way. A draw is not a terrible result for either side, but you feel that there will be a few more chances before this game is through.
56 min SAVE! Ederson comes for a second corner in the space of a minute and again does not claim it cleanly. Salah picks it up on the right flank before curling one towards goal from a long way out which Ederson needs to tip over the top.
56 min CHANCES! A couple of chances in quick succession for Liverpool as Ederson comes to claim a corner, only to flap at it and divert it straight to Salah. Salah drives it powerfully towards goal, but Ederson recovers well to parry the ball away. Man City look like they may be on the counter straight after, but Liverpool win the ball back again and get it to Oxlade-Chamberlain, who cuts inside his man down the left channel before drilling a low strike towards the near post with Ederson gets down well to push wide.
55 min The second half has quickly fallen into a similar pattern to the first, with both teams playing quick football and focused on going forward every time they get the ball.
53 min Man City are looking increasingly dangerous here as De Bruyne tries another low cross into the box from the right flank, but again Aguero can't get to it.
51 min OFF THE CROSSBAR! Man City immediately break and good work from De Bruyne and Sterling eventually sees the ball fall to the feet of Aguero, whose first-time effort is blocked behind by Matip. Otamendi rises highest from the resulting corner and plants a superb header towards goal, only to see it crash against the crossbar with Karius beaten.
50 min Really good play from Gomez as he beats Danilo and Gundogan down the right flank before swinging a low cross into the box which Ederson does well to claim.
48 min Ederson is quickly off his line to mop up a Mane through-ball which was being chased by Firmino. Good, alert goalkeeping from the City man again there.
46 min KICKOFF: Man City get us back underway for the second half at Anfield!
The first half comes to an end at Anfield, and it is all square after a really high-quality opening 45 minutes between Liverpool and Manchester City.
Both sides have played with a good tempo and intensity, with the game living up to the billing so far. It is still all to play for in the second half, and both sides will be believing that they can go on to win this game.
45+2 min HALF TIME: Liverpool 1-1 Manchester City
45+1 min There will be two minutes of added time at the end of this first half.
45 min SHOT! Man City break quickly and Fernandinho comes into shooting space before letting fly, but he drags his effort comfortably wide.
43 min Oxlade-Chamberlain has been really bright in this first half, and he again threatens here by reaching the byline and winning a corner.
41 min Out of nothing, Man City have the equaliser just before half time!
It is a really good goal from Sane too as he collects a long ball on his chest, with his first touch taking Gomez out of the game. He cuts inside before then going back on to his left foot and slamming a powerful effort past Karius at the near post. Karius should have done better, but take nothing away from Sane there.
41 min GOAL! Liverpool 1-1 Manchester City (Leroy Sane)
39 min SAVE! Salah threatens again here as he cuts inside onto his deadly left foot of his before curling an effort towards goal. It is an ambitious strike, though, and Ederson is able to make a comfortable save.
37 min Brilliant work from Liverpool to win the ball back inside their own half just when Man City's threat seemed to be beginning to grow. They quickly launch a counter and ball is played through for Salah, but he cannot add to Liverpool's lead.
35 min SAVE! De Bruyne picks up the ball around 27 yards from goal and drives a low strike towards the bottom corner, but he doesn't catch it perfectly and Karius makes a fairly comfortable save.
34 min Liverpool almost break through again here as Mane slides a pass through for Firmino, but the Brazilian's touch lets him down.
33 min Better from Liverpool in terms of getting close to De Bruyne as first Wijnaldum and then Mane make life difficult for the Belgian. Liverpool give away a free kick, but they need to keep that close an eye on him.
31 min CHANCE! Half a chance for Liverpool here, and again Oxlade-Chamberlain is involved. He wins two duels against Man City players to break down the right before whipping a cross into the box which Firmino can only glance wide of the near post.
31 min MAN CITY SUB: Delph will not be able to soldier on after all as he limps off to be replaced by Danilo.
30 min De Bruyne is beginning to have a growing influence on this game, which needs to be ringing alarm bells for Liverpool. The Belgian hasn't managed to do any damage so far, but it could only be a matter of time.
28 min This is now already Oxlade-Chamberlain's highest-scoring Premier League season too. What must Arsene Wenger be thinking on a day when his side fell to another disappointing defeat?
26 min It looked as though Man City may be forced into an early change here as Delph goes down and Danilo is on the sidelines ready to come on. Delph insists that he is fine to continue, though, and the change is put on hold.
25 min Liverpool come forward for the first time in a while as Mane slides a pass down the left channel for Wijnaldum, but Mane is then caught on his heels for the return ball and it is picked off. That would have been a good chance too.
23 min SHOT! De Bruyne pings a pass over to Sterling, who in turn knocks it back inside for Sane. Sane has a bit of space to shoot from outside the box, and his effort deflects wide of the target with Karius completely wrong-footed.
23 min Man City are enjoying a good spell here. They have dominated possession over the past five minutes or so and are beginning to press Liverpool back into their own half now.
20 min CLOSE! De Bruyne is involved again here as he swings a low cross into the box which is just begging to tapped in. Aguero is just short of getting the decisive touch, although the Argentine was offside anyway.
19 min De Bruyne looks to slide a ball through to Sterling, but it is cleared out for a throw-in. It was a brilliant piece of vision for De Bruyne, but he just didn't put enough on the pass this time.
17 min There is space for Liverpool to attack behind the Man City defence here, and they are not shy about exposing it. The hosts have started really well here.
15 min CHANCE! Another bright break from Liverpool as Mane escapes down the left flank, but he cannot find a pass as the attack slows down. He ends up back-heeling it into the path of Salah, but he can't get a shot away. Moments later Salah picks up possession in the box, but Otamendi slows him down and Salah can then only poke it past the near post.
13 min City look for a quick response as De Bruyne brings the ball forward before slipping a pass to Sterling down the right channel but, much to the delight of the Anfield faithful, the linesman's flag goes up against the pantomime villain.
11 min There is still a long way to go in this match, of course, but Jurgen Klopp will be delighted to have got that early goal. It should also be a good one for the neutrals as City now need to attack even more, and Liverpool are not exactly a team to sit back.
9 min What a start for Liverpool, and it is Alex Oxlade-Chamberlain who sends Anfield wild with a brilliant opening goal!
The midfielder wins possession off Delph and immediately drives forward towards the edge of the area before letting fly from around 25 yards out. It is hard, low and right in the corner to beat Ederson and give Liverpool the lead over City!
9 min GOAL! Liverpool 1-0 Manchester City (Alex Oxlade-Chamberlain)
7 min This certainly isn't going to improve Sterling's popularity inside Anfield. The winger collects De Bruyne's pass in the area and beats Can to the ball, but they throws himself to the floor far too easily. Not enough in that one for a penalty.
5 min Sterling is predictably getting heavily booed every time he gets on the ball following his acrimonious departure from Liverpool a couple of years ago. These Liverpool fans certainly haven't forgotten.
3 min Plenty of possession early on for Liverpool, and they almost break through for the first time. Mane looks like he is clean through on goal following a flick on from Firmino, but the winger's first touch lets him down. Salah picks up the loose ball, but sees his subsequent effort blocked.
1 min KICKOFF: Here we go then! Liverpool get us underway amid a raucous atmosphere at Anfield!