Sixth-placed Arsenal sit four points and three places behind their bitter rivals entering this afternoon's clash.
Three of the last four fixtures between these two teams have finished level – including a 1-1 draw in the corresponding Premier League match last term.
Stay tuned for live minute-by-minute updates of the action.
OFFICIAL LINE UPS
ARSENAL: Cech; Koscielny, Mustafi, Monreal; Bellerin, Ramsey, Xhaka, Kolasinac; Ozil, Lacazette, Sanchez
TOTTENHAM HOTSPUR: Lloris; Dier, Sanchez, Vertonghen; Trippier, Dembele, Sissoko, Davies; Eriksen, Kane, Alli
The referee brings the second period to a close with Arsenal recording a 2-0 win over Tottenham to move onto 22 points in the Premier League table. What a performance from the Gunners. Thanks for joining our live coverage once again!
90+5 min FULL-TIME: Arsenal 2-0 Tottenham
90+4 min Son has one deflected over the crossbar as Tottenham come close late on.
90+3 min Iwobi misses the post with a low strike from outside the Tottenham box.
90+3 min Trippier delivers towards Llorente, but Koscielny is on hand to clear once again as Arsenal close on another three points at home. Alexis Sanchez comes close to making it three as he races into the Tottenham box, but the Chilean cannot beat Lloris, who makes a smart save!
90+1 min We are into the first of four additional minutes at the end of the 90 here, and Xhaka has just sent a free kick wide of the post. Still time for some late drama at the Emirates Stadium!
88 min Possession for Tottenham, but Arsenal are holding off their rivals as we enter the final moments. Alexis Sanchez has the chance to break away down the other end, but the Chilean's final ball is poor.
86 min CHANCE! Super chance for Son, who races onto a header from Llorente, but his effort is over the crossbar! That was a big moment for the away side here!
85 min ARSENAL SUB! Iwobi replaces Ozil for the home side.
83 min Bellerin has a strike blocked following another quick counter from the home side. Tottenham are getting caught time and time again due to the fact that they have to commit men forward.
82 min SAVE! Brilliant save from Cech to keep out Dier's close-range header!
80 min Plenty of possession for Tottenham at the moment, but not an awful lot else.
78 min Little over 10 minutes of football remaining, and Arsenal still lead 2-0. Not too much to report in terms of chances in the last few moments, which is exactly what the Gunners would want.
76 min SAVE! Super save from Lloris to keep out Sanchez from close range!
75 min TOTTENHAM SUBS! Llorente and Son replace Alli and Kane.
74 min ARSENAL SUB! Coquelin replaces Lacazette for the home side.
73 min BOOKING! Monreal (Arsenal) is booked for a late challenge on Alli.
71 min Another chance for Sanchez, but the Chilean's effort is weak and straight at Lloris.
71 min Sanchez strikes one over the Tottenham crossbar following another slick passing move. Tottenham are just struggling to keep the ball at the moment as the home side enjoy a good spell once again.
69 min Alexis Sanchez wins a foul in a wide area as Tottenham's counter is cut short.
67 min You just wonder whether Pochettino will look to introduce Llorente in the final stages of this match. As for Arsenal, Wenger might well look to freshen the middle of his midfield. We are at a key stage of the contest as the home side decide whether to drop deep or go for a third goal to kill the game.
65 min Little over 25 minutes of football remaining at the Emirates Stadium, and Arsenal still lead 2-0. Not too much has happened in the second period in terms of clear opportunities here.
63 min Eriksen sends one into the stands from outside the Arsenal box.
62 min TOTTENHAM SUB! Winks replaces Dembele for the away team.
61 min Tottenham continue to pass and probe in the final third, but they are leaving space down the other end for Arsenal to break, and the home side are committing plenty of players forward. I would be astounded if we had seen the end of the goals here. It has been a brilliant game of football thus far.
58 min Little over 30 minutes of football remaining here, and Arsenal still lead 2-0. Tottenham are fighting their way back into the match, but they are just missing that final piece of magic in attack.
56 min Ozil shows excellent feet in a tight area as the German leads a counter-attack, but Sanchez's final pass into the attacker is just too strong. Tottenham then go down the other end with Kane, but the striker's effort is defected wide of the post. All-action stuff in the North London derby here!
54 min Davies delivers a dangerous cross into the Arsenal box, but Monreal is on hand to make the clearance. Good pressure from Tottenham as the second period begins to gather pace here.
52 min The next goal in this match is absolutely massive. If Arsenal score a third then it would probably be game over at this stage, but one for Tottenham would make things very interesting indeed.
50 min BOOKING! Kane (Tottenham) is booked for a late tackle on Xhaka.
49 min Half-chance for Tottenham as Dembele delivers a cross towards Kane, but the striker's header is comfortable for Cech. It has been a decent start to the second period from the visitors here.
48 min BOOKING! Mustafi (Arsenal) is booked for a foul on Kane.
48 min... no changes from either side at the break, which is not too much of a surprise. However, I suspect that both managers will have alterations in mind as the second period develops in the capital.
46 min RESTART! Arsenal resume the action on home soil...
The referee brings the first period to a close with Arsenal leading Tottenham 2-0 courtesy of goals from Mustafi and Alexis Sanchez. Both goals looked a touch offside, but there is no question that Arsenal were the better team in what was a brilliant first 45 minutes of action.
45+2 min HALF-TIME: Arsenal 2-0 Tottenham
45+1 min We are into the first of two additional minutes at the end of the first period.
44 min WIDE! Kane has a good opening, but sends his effort wide of the post!
44 min Tottenham need a goal, and they need one quickly. Spurs have been poor in this first period.
42 min Arsenal double their lead in the 41st minute as Sanchez smashes home from close range after Lacazette had delivered a low cross into the Chilean. What a moment!
41 min GOAL! Arsenal 2-0 Tottenham (Sanchez)
40 min Tottenham will be extremely unhappy about the set piece which led to the Arsenal goal, while Mustafi might well have been offside. Not great! Spurs have not been at it this afternoon though.
38 min BOOKING! Sanchez (Arsenal) is booked for a foul on Davinson Sanchez.
37 min Arsenal make the breakthrough in the 36th minute as Mustafi rises to head an Ozil free kick into the top corner. It is a super header from the German international!
36 min GOAL! Arsenal 1-0 Tottenham (Mustafi)
36 min Good pressure from Tottenham in the last few moments as they again threaten in a wide area. Davies delivers towards Kane once again, but Mustafi is on hand to make the clearance. Arsenal then break through Sanchez, and Davinson Sanchez is penalised for a foul on the Chilean!
34 min SAVE! Cech rises to keep out a towering header from Kane!
33 min POST! Eriksen hits the post for Spurs after working space inside the Arsenal box!
32 min BOOKING! Xhaka (Arsenal) is booked for a late tackle on Alli.
32 min Eriksen slides a pass towards Kane inside the Arsenal box, but Cech is out to collect.
32 minTottenham just cannot seem to break at the moment as Arsenal continue to chase down the lose ball. The Gunners have been at it all over the park, but the score is still goalless, which will be a slight worry. It has been a brilliant 32 minutes of football despite the fact there are no goals here.
30 min Smart defending from Dier sees Tottenham clear behind for a corner after Ozil had broken into the penalty box once again. Arsenal are really forcing the issue with 30 minutes on the clock.
28 min Davies delivers a super cross into the Arsenal box, but Kane cannot make clean contact under pressure from Monreal. Arsenal then break down the other end with Sanchez, who finds Lacazette, but Lloris is on hand to make the clearance. It is all happening at the Emirates Stadium.
26 min More pressure from Arsenal following a break down the left, but Sanchez is across to make the challenge, and the resulting corner is also cleared. Tottenham are being seriously tested here.
24 min Xhaka is fortunate to escape a booking following a late challenge on Sissoko. Lucky!
24 min Sanchez finds space in a dangerous area following a corner, but the Chilean's cross is poor. Sanchez has another chance to deliver moments later, but the danger is cleared once again.
22 min Tottenham are being forced to defend their own penalty box at the moment as Arsenal continue to force the issue in the final third of the field. There has not been a yellow card in this match, but there have been some tasty challenges - the last of which sees Vertonghen go through Lacazette.
19 min CHANCE! Super chance for Arsenal as Ramsey delivers a brilliant pass into Bellerin, who flashes a low cross into the Tottenham box, but Lacazette just cannot make contact!
17 min Alli works some space inside the Arsenal box after smart work from Sissoko, but the attacker's strike is blocked. Good pressure from the visitors as they start to find their passing range.
15 min Kane somehow stays onside as he collects the ball in a wide area, but Arsenal sniff out the danger once again. I would be astounded if there were not goals this afternoon - it has been a super start.
13 min Sanchez heads towards Lacazette as Arsenal threaten once again, but Sanchez does well to poke the ball clear at the vital moment. Tottenham just need to be careful here.
12 min It must be said that the first 12 minutes of this match have flown past. Both teams have had decent chances to make the breakthrough, but the score remains goalless. Sanchez and Ozil both look fired-up this afternoon as they continue to chase down loose balls. It is a really good game.
10 min Davies fires the ball straight out of play as Arsenal continue to press high up the field. The home supporters like what they are seeing here. The team in red and white look very much up for this.
8 min Well, sometimes games of this ilk are cagey, but that has not been the case thus far. Eight minutes on the clock and this is a proper derby as both teams continue to fly into challenges here.
6 min SAVE! Cech has to keep out a powerful strike from Kane following a mistake from Koscielny, whose header was weak. Both defences are making mistakes in the early moments.
6 min Alli has the chance to find Eriksen with a pass as Arsenal are caught up the field, but the England international takes too long, and the home side can clear their lines. Arsenal then have a half-chance as Sanchez feeds Lacazette in a dangerous area, but the forward's effort is too high.
4 min As expected, it has been all-action in the early stages, with both teams battling for possession. It might take a while for both to settle into some sort of rhythm. Nice flow to the game thus far.
2 min... it must be said that there is a wonderful atmosphere inside the stadium this afternoon - let's hope that the football matches it. It is a rainy afternoon in the capital, which has made the pitch moist. You do get the feeling that there will be goals in this one. Hopefully I have not jinxed it.
0 min KICKOFF! Tottenham kick things off at the Emirates Stadium...