The Chipolopolo are three points behind the Super Eagles, following their back-to-back victories over Algeria.
A victory in Uyo would put them in pole position to qualify for their first-ever World Cup.
Nigeria however need just a point, to qualify and Nyirenda has already lined-up up his preliminary squad for the showdown on October 7.
Zambia provisional squad in full:
Goalkeepers: Toaster Nsabata (Zanaco) , Kelvin Malunga (Nkana)
Defenders: Simon Silwimba (Zesco United), Fackson Kapumbu (Zesco United), Ziyo Tembo (Zanaco), Donashano Malama (Nkana), Boston Muchindu (Nkana), Moses Nyondo (Nkana), Adrian Chama (Green Buffaloes), Isaac Shamushopa (Power Dynamos)
Midfielders: Godfrey Ngwenya (Power Dynamos), Kondwani Mtonga (Zesco United), John Ching’andu (Zesco United), Ernest Mbewe (Zanaco), Augustine Mulenga (Zanaco), Webster Mulenga (Red Arrows)
Forwards: Martin Phiri (Power Dynamos), Alex Ng’onga (Power Dynamos) , Lubinda Mundia (Red Arrows), Lameck Banda (Nkwazi).