Nigeria takes on the Chipolopolo at the Godswill Akpabio International Stadium on October 7, looking to secure the points that will see them clinch the sole ticket from Group B.
Ighalo is one of the strikers that coach Gernot Rohr has called up for the match.
“I’m happy to be called up again because it’s always a great honour to play for my country,” Ighalo told BBC Sport.
“We know Zambia is a strong team and they will come with full determination in Uyo, we cannot engage in irrelevant pre-match talking but deliver on the pitch.
“I’ve never played at the World Cup and like my other colleagues, we all want to be in Russia, this is like a final for us.”