A goal apiece from Odion Ighalo, Chelsea FC winger, Victor Moses; skipper Mikel Obi and substitute Kelechi Iheanacho ensured Nigeria grabbed the maximum three points at the Akwa Ibom Stadium in Uyo.
After a sluggish start, Ighalo puts Nigeria ahead after receiving a fine pass from Mikel in the 28th minute. The China-based forward, however, got yellow-carded for taking off his jersey while celebrating.
Mikel made it 2-0 in the 42nd when he latched onto a Victor Moses corner.
Eleven minutes into the second half, Victor Moses combined with gangling winger Moses Simon before slotting home from inside the box.
Iheanacho, who came in for injured Ighalo, made it 4-0 when he nodded past goalkeeper Fabrice Ondo from Ogenyi Onasi assist in 77th minute.
With the victory, Nigeria top Group B with nine points, while Cameroon have just two points from three matches.