Manchester United's reward for beating city rivals City is an EFL Cup quarter-final match against West Ham.
Arsenal will play host to Southampton, while Liverpool host Leeds United and Newcastle go to Hull.
The last time the Red Devils played the Hammers in cup competition, it was in the FA Cup last season. It took a replay for Louis van Gaal's side to come through on that occasion, yet it paved the way to their success in the FA Cup.
However, West Ham's last League Cup meeting with the Old Trafford club ended emphatically in their favour, with a 4-0 win in 2010-11.
Arsenal, meanwhile, have lost their last three home League Cup ties against Premier League opponents - including a 2-1 reverse against Saints two years ago.