Valencia have dismissed coach Pako Ayestaran with the side bottom of La Liga having lost their opening four games of the season.
Ayestaran, 53, replaced Gary Neville last March but the Spanish club have lost eight out of 12 games under his stewardship.
His final match in charge was the 2-1 defeat at Athletic Bilbao on Sunday.
Salvador Gonzalez Marco, also known as 'Voro', will take over as caretaker coach for a fourth time.
He was previously put in charge when Nuno Espirito Santo resigned in November 2015.
Ayestaran was Newcastle manager Rafael Benitez's assistant at five clubs, including Valencia and Liverpool.