Nwosu who weights 71.10, claimed the gold with a lift of 140 kg.
In second position was Souhad Ghazouani from France who won silver also with a lift of 140.
Egypt's Amany Ali finished third to take the bronze medal after lifting 127 kg.
Nwosu now joins Roland Ezuruike (men's -54kg), Paul Kehinde (men's -65kg) and Lucy Ejike (women's -61kg) as gold medalists for Team Nigeria in the powerlifting event.
With Nwosu's latest feat, Team Nigeria now has five gold medals and is ninth position in the overall medal standings.